Morning, long-lifers. Here’s what’s new:

Blood swap therapy cuts 2.6 years off biological age — because apparently, the fountain of youth now accepts plasma donations.

Guess it’s time to trade your green juice for a group IV session.

Don’t keep longer. a secret—share it with your friends!

This week in longevity:

• 🐁 Drug duo boosts mouse lifespan by 35%

• 🌞 Vitamin D slows cell aging in 4-year trial

• ☕️ Coffee linked to disease-free aging in women

• 🧠 Sedentary life tied to faster brain decline

• 🧬 Klotho gene therapy extends lifespan 20%

• Plus, more longevity breakthroughs.

Read time: 5 minutes

THIS WEEK IN LONGEVITY

🩸 Plasma swap shows promise for reversing biological age

A new human trial from Circulate Health and the Buck Institute found that therapeutic plasma exchange (TPE) — especially when combined with immune-boosting IVIG — reduced biological age by over 2.5 years. Think of it like a tune-up for your blood, and maybe your immune system, too.

What to know:

• TPE = a blood refresh: The process filters out old plasma (which can hold inflammatory proteins and other age-related gunk) and replaces it with clean fluid like albumin or donor plasma.

• Combo worked better: People who got both TPE and IVIG (a concentrated immune protein) saw double the age reduction compared to TPE alone — 2.6 years versus 1.3 years on average.

• Multi-system effects: The treatment shifted immune cell patterns, lowered markers linked to cellular aging, and even improved physical strength and balance in older adults.

• Bigger results for less healthy folks: Participants with signs of metabolic stress — like high blood sugar or liver enzymes — saw the most dramatic age reversal.

• Most of the benefit came early: After about three treatments, improvements started to level off. Researchers think fewer sessions or smarter combos could work even better.

The head of Circulate’s new advisory board is so optimistic, he’s personally starting treatment this week — a rare flex in longevity science.

Why it’s important: This isn’t just about looking younger — it’s about shifting the biology under the hood. If TPE holds up in larger trials, it could become a core tool for fighting age-related decline. Turns out, a little bloodwork might be more powerful than another green smoothie.

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⏳ Lifespan stretched 30% with drug combo

A newly published study in Nature Aging found that combining rapamycin with trametinib — two drugs originally used for cancer and immune suppression — extended mouse lifespan by up to 35%. It beat either drug alone and even held up after cancer deaths were removed. Not bad for a pair of repurposed meds.

What to know:

• Combo beat the single drugs: Rapamycin alone helped as expected. Trametinib added a modest bump. But together, they boosted median lifespan by 35% in females and 27% in males.

• It wasn’t just fewer tumors: The combo lowered liver and spleen cancer rates, but the longevity effect remained even when cancer deaths were excluded — suggesting broader anti-aging effects.

• Heart and brain got a lift too: Mice on the combo kept younger heart rhythms and showed less brain inflammation (fewer overactive immune cells in the brain).

• Big, serious mouse trial: With over 800 mice and detailed physical and biological testing, this was one of the most robust aging drug studies to date.

• Side effects stayed the same: Rapamycin’s downsides (like increased blood sugar and fat gain in females) weren’t made worse by trametinib — but they weren’t fixed either.

If rapamycin is the heavyweight of aging drugs, trametinib might be the scrappy tag-team partner it needed.

Why it’s important: Mouse results aren’t a direct pass to human use — but this shows that stacking targeted drugs can do more than one at a time. It’s a glimpse at what future anti-aging regimens might look like: smart combinations, not silver bullets. Aging may be complex, but mice just showed us it’s not unbeatable.

💡 Want to break down a research article? Try this prompt in ChatGPT:
“Explain this in plain language. Avoid science terms. Keep it under 5 sentences. Then give 5 takeaways based only on this summary—no extra info or guesses: [Paste the article here]”

 MONEY MOVES IN LONGEVITY

💰 Magnitude Biosciences lands £700K+ to scale its worm-based drug screening tech—tiny nematodes, major longevity gains.

💰 Vivodyne raises $40M to scale robotic testing on human tissues—animal models out, 95% failure rate in the crosshairs.

💰 Omada Health announces IPO with shares priced at $18–$20—virtual care steps onto Wall Street’s main stage.

💰 OpenEvidence in talks to raise $100M+ at $3B valuation—AI’s white coat moment gets a clinical upgrade.

 IN THE SPOTLIGHT

1. Vitamin D may slow cellular aging, study finds
A 4-year trial found daily 2,000 IU vitamin D preserved telomeres—DNA caps that shrink with age—by about 140 base pairs. That’s roughly 3 years of aging. Benefits were strongest in healthy, normal-weight adults under 64 not on certain meds. Chalk one up for the sunny side of supplements.

2. Sedentary lifestyle tied to faster brain aging
Middle-aged adults who stayed inactive had more brain shrinkage and Alzheimer’s markers than those who upped their activity. Movement seems to protect the mind. Even becoming active later helped—brain benefits showed up in just four years. It’s never too late to start moving.

3. Daily coffee linked to healthier aging in women
A long-term study of 47,000 women found that midlife coffee drinkers had better odds of aging without disease, disability, or memory issues. Each extra daily cup bumped their chances of healthy aging by up to 5%. Turns out, your morning brew may be brewing up resilience.

THE NEXT BIG THING

Longevity Science Meets Fitness

Tally Health just teamed up with Pvolve and Cenegenics to bring personalized, preventive aging to the mainstream.

The Pvolve collab merges epigenetic testing, supplements, and functional movement into one bundled program—with over 1,500 classes and private coaching. Cenegenics adds Tally’s DNA-based aging clock to its national clinics, giving patients deeper insight into their biological age and response to interventions.

New era of aging—or just marketing?

WHAT ELSE YOU SHOULD KNOW THIS WEEK

🧪 Supplement Surge: Longevity supplements are exploding in popularity, with healthspan (years lived in good health) now a top goal for millions. NMN, resveratrol, and spermidine show real anti-aging promise.

🥦 Ovarian Boost: A 3-year 30% calorie cut delayed ovarian aging in perimenopausal monkeys, boosting follicle count and reducing fibrosis (tissue stiffening). Timing mattered—benefits only showed before full menopause.

🧬 Klotho Lift: Gene therapy boosting klotho protein extended mice lifespan by 20% and improved muscle, bone, brain, and immune health. Delivered via dual brain-body injection, it reduced aging damage across organs.

🌍 Doctor Network: Dr. David Luu’s Longevity Docs connects 400 physicians in 50 countries to scale prevention-focused, evidence-based longevity care. What started as a WhatsApp group is now a global clinical movement.

🧠 Aging Reset: Aging-US editor Marco Demaria urges a healthcare overhaul to target aging biology, not just diseases. His “third paradigm” pushes prevention before damage starts, slashing future health costs.

WHAT WE’RE BOOKMARKING

📱 Social

🎧 Podcasts

📰 Articles

⚙️ Tools to Try

Thanks for reading.

See you in the next issue.

Anna

DISCLAIMER: The information provided in this newsletter is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making any changes to your health or wellness routine.