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Combining vitamin D and probiotics might reverse biological age by 11 years—proving that supplements can do more than just collect dust on your shelf.

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This week in longevity:

• 🏃‍♂️ Exercise slashes cancer progression risks

• 🧃 Elderberry juice boosts metabolism, gut health

• 🐀 Intermittent fasting reverses high blood pressure in rats

• ❄️ Brown fat improves endurance and longevity

• 🧠 Brain aging hotspot linked to metabolism

• Plus, more longevity breakthroughs.

Read time: 5 minutes

THIS WEEK IN LONGEVITY

FEATURED

🦠 Vitamin D + Probiotics: A Potential Anti-Aging Duo

A new study suggests combining vitamin D with specific probiotics can reverse biological age by an average of 11 years and boost immune function. This pilot research offers a fresh perspective on how gut health impacts aging and overall vitality.

What to know:

• The combo works: Participants took vitamin D with three probiotic strains daily (Bifidobacterium animalis, Lactobacillus reuteri, and Lactobacillus plantarum). After two months, their biological age dropped by an average of 11 years.

• Immune boost: Researchers found improved activity in natural killer cells—immune cells that help fight diseases.

• Targets aging drivers: The combination reduced oxidative stress and inflammation, two key processes that accelerate cellular aging.

• Biological vs. chronological age: Biological age reflects how "old" your cells are. Participants had an average biological age of 58 years before the study, despite being 48 chronologically. The treatment reversed this trend.

• Small-scale study: Only 24 participants were included, and there was no control group, so more research is needed to confirm the findings.

Why it’s important: This study highlights the exciting link between gut health and aging. While more research is needed, it supports the idea that improving the gut microbiome through probiotics and vitamin D could offer a practical way to boost health and longevity. Imagine adding a few simple supplements to your routine and giving your body a youthful edge!

FEATURED

🏃‍♂️ Exercise Before Cancer Diagnosis Reduces Risks

New research shows that regular physical activity before a cancer diagnosis can significantly lower the risks of disease progression and death. Published in the British Journal of Sports Medicine, the study emphasizes how even small amounts of exercise can make a difference.

What to know:

• Study highlights: Researchers analyzed data from over 28,000 cancer patients in South Africa, tracking their physical activity in the year before diagnosis.

• Progression risk drops: Cancer patients who exercised moderately to intensely were 27% less likely to experience disease progression compared to those who didn’t exercise.

• Survival boost: The odds of surviving cancer were 47% higher for those with moderate to high exercise levels, and 33% higher for low activity levels, compared to no activity.

• Consistency matters: Patients who exercised regularly had higher survival rates over 2, 3, and 5 years post-diagnosis.

• Immune benefits: Exercise likely strengthens immunity, boosts natural killer cells, and regulates hormones like estrogen and testosterone, which may slow cancer growth.

Why it’s important: This study reinforces the role of exercise not just in cancer prevention but also in improving outcomes for those diagnosed with the disease. A short daily walk or light workout could help patients live longer and better. Encouraging physical activity is a simple, powerful way to support cancer care and recovery.

💡Pro Tip: Want to dive deeper? Use tools like ChatGPT, Claude, or Gemini to simplify complex studies. Copy, paste, and get a clear summary—it’s like having a personal research assistant.

IN THE SPOTLIGHT

1. Intermittent Fasting Lowers Age-Related High Blood Pressure in Rats
New research shows that intermittent fasting can counteract age-related hypertension in rats. By restoring balance in the renin-angiotensin system (a key regulator of blood pressure and kidney function), fasting every other day reduced blood pressure to levels seen in younger animals. This study underscores the potential of fasting as a natural strategy for maintaining cardiovascular health with age.

2. Elderberry Juice Boosts Metabolism and Gut Health
A Washington State University study found that drinking elderberry juice can improve metabolic health and aid weight management. Overweight participants in a clinical trial saw better glucose tolerance, reduced insulin levels, and increased fat oxidation after consuming 12 ounces daily for a week. The findings also revealed positive changes in gut bacteria, highlighting elderberry’s potential as a functional health beverage.

3. Brown Fat Enhances Exercise and Supports Longevity
A Rutgers study highlights how brown adipose tissue (BAT) can improve physical performance and promote healthy aging. BAT, a calorie-burning fat that generates heat, was shown to directly increase endurance and reduce muscle decline in mice. These findings pave the way for potential therapies that harness BAT’s unique properties to fight metabolic decline and age-related health issues.

LONGEVITY SNAPSHOTS

WHAT ELSE YOU SHOULD KNOW THIS WEEK

💉 Billionaire Longevity: Jeff Bezos, Sam Altman, and Peter Thiel are driving a $25B anti-aging boom with breakthroughs like Alzheimer’s fixes and organ preservation. While innovations promise to make 90 the new 50, billion-dollar regulatory hurdles slow progress.

🧠 Aging Hotspot: Scientists at the Allen Institute found an "aging hotspot" in the hypothalamus where key brain cell functions decline with age. The discovery links brain aging to metabolism and inflammation, opening the door to targeted anti-aging treatments.

🧠 Fluoride & IQ: A meta-analysis links high fluoride exposure to lower IQ in children, with a 1 mg/L increase in fluoride reducing IQ by 1.63 points. Most studies show an inverse relationship, but geographic bias and study limitations call for further research.

🏃‍♂️ Muscle Monitor: Australian researchers developed the OxiDx fingerprick blood test to detect hidden muscle damage and track recovery in athletes. By measuring protein biomarkers, the test helps prevent premature training, reducing injury risk and speeding up recovery.

🎮 Virtual Healing: Stroke survivors regain motor skills using NeuRRoVR, a virtual reality system developed at the University of Michigan. By enhancing brain plasticity through immersive games, this tech boosts recovery while tailoring difficulty for patient progress.

PROMPT OF THE DAY

Cold Exposure

WHAT WE’RE BOOKMARKING

📱 Social

🎧 Podcasts

• Culture Apothecary with Alex Clark: "Why The Tongue Is The Secret Window To Your Health & Other Hacks | Dr. Josh Axe": Discover how your tongue reveals your health and why raw honey still matters (Spotify link).

• Andrew Huberman: "How to Use Exercise to Improve Your Brain’s Health, Longevity & Performance": Learn how to time and tailor exercise to boost brain health, neuroplasticity, and learning (Youtube link).

📚 Books

• "Radical Longevity" by Ann Louise Gittleman, PhD, CNS: Unlock a science-backed plan to reverse aging symptoms, enhance immunity, and boost vitality with targeted nutrition and lifestyle tweaks (Amazon link).

⚙️ Tools to Try

• LARQ PureVis Self-Cleaning Water Bottle: Stay hydrated with a bottle that cleans itself and your water using UV-C tech (Amazon link).

Thanks for reading.

See you in the next issue.

Anna

DISCLAIMER: The information provided in this newsletter is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making any changes to your health or wellness routine.