Morning, long-lifers. Here’s what’s new:

Creatine eases constipation — who knew bulking season was also bathroom season. Turns out, a meat-heavy diet might do more for your gut than your glutes.

Your blender bottle’s about to feel very left out.

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This week in longevity:

• 🧠 Green tea + B3 revive aging brain cells

• 🧫 Mini organs grow their own blood vessels

• 🪲 Cold exposure slows aging in wasps

• 💡 $160K wellness pod claims instant rejuvenation

• 🌿 Nature daydreaming boosts mental focus

• Plus, more longevity breakthroughs.

Read time: 5 minutes

THIS WEEK IN LONGEVITY

💪 Creatine supports gut motility and reduces constipation

People who eat more creatine, mostly from meat and fish, tend to have fewer issues with chronic constipation. The effect showed up most in younger, healthier men. Not all gut fixes need to come from fiber or fermented drinks.

What to know:

• Creatine from food, not powders: The benefit came from eating meat and fish, not from using supplements.

• Lower constipation risk: A tenfold increase in creatine intake was linked to a 19 percent drop in constipation risk.

• Most effective in certain groups: The effect was strongest in men under 48 without diabetes or high blood pressure.

• How it works: Creatine improves hydration in gut cells and supports intestinal motility, the muscle movements that keep digestion flowing.

• Observational data only: The study used survey data and cannot prove that creatine directly causes the improvement.

Why it’s important: Many common constipation remedies are either unpleasant or unreliable. Creatine might offer a gentler, food-based option for people who already include it in their diet. Your muscles are not the only ones that get sluggish without it.

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🧠 Green tea + B3 combo revives aging brain cells

UC Irvine scientists found that a mix of green tea antioxidants and vitamin B3 can revive aging brain cells, at least in lab tests. By restoring a key energy molecule (GTP), the treatment helped old neurons clean up harmful Alzheimer’s proteins. Think of it as a cellular spring cleaning powered by pantry staples.

What to know:

• The combo: Researchers used nicotinamide (a form of vitamin B3) and epigallocatechin gallate (an antioxidant from green tea).

• What it does: It restored levels of GTP (guanosine triphosphate), a key molecule that powers brain cell activity and cleanup.

• Why that matters: Low GTP in older brain cells weakens autophagy (the brain’s cleanup process), leading to buildup of amyloid beta (a hallmark of Alzheimer’s).

• Lab results only (so far): In neurons from Alzheimer’s model mice, GTP levels rebounded in just 24 hours, improving energy use and clearing toxic proteins.

• Oral dose challenges: Nicotinamide supplements may not work well when taken by mouth. It’s often inactivated before reaching the brain.

Why it’s important: This could point to a new way to slow cognitive aging. Using safe, natural compounds that already exist in supplements. But it’s not ready for your medicine cabinet just yet. A molecule called GTP may not sound exciting, but your neurons think it’s gold.

💡 Want to break down a research article? Try this prompt in ChatGPT:
“Explain this in plain language. Avoid science terms. Keep it under 5 sentences. Then give 5 takeaways based only on this summary—no extra info or guesses: [Paste the article here]”

 MONEY MOVES IN LONGEVITY

💰 Sava lands $1.9M for its real-time biosensor platform. Turns sweat into a data stream for health insights.

💰 Comanche gets $3M from Gates Foundation for women’s health R&D. Finally, the funding gap gets a dent.

 IN THE SPOTLIGHT

1. B vitamins linked to brain and heart health
New research highlights how B12, folate, and other B vitamins affect cognition, heart disease, stroke risk, and even inflammation. Better screening could catch hidden deficiencies. Forget pricey Alzheimer’s drugs—some brain decline might just need a B12 test and a few cents’ worth of vitamins.

2. Gene-edited stem cells reverse aging in monkeys
Scientists gave aged monkeys stem cells engineered with a “longevity gene” tweak, leading to cognitive, immune, bone, and reproductive rejuvenation. Aging clocks reversed by years. Think of it as stem cells 2.0—these didn’t just help, they turned back the biological clock in multiple organs.

3. Gene therapy edges closer to tackling aging
Scientists are learning how to tweak genes to slow aging, but getting treatments into the right cells across the body is still really tricky. It’s like having a powerful tool with no reliable way to aim it, and researchers are racing to fix that problem.

THE NEXT BIG THING

Smartphones as brain health monitors

A UK startup just launched a smartphone-based platform in the US to detect early signs of Parkinson’s and dementia.

Neu Health’s tool uses phone sensors, guided at-home tasks, and AI-trained algorithms to monitor speech, memory, motor skills, and cognition. No wearables needed. The goal: catch neurological decline up to 18 months earlier and support proactive, home-based care.

New standard for brain care or niche tool?

WHAT ELSE YOU SHOULD KNOW THIS WEEK

⌚️ Heart Forecast: University of Texas at Arlington researchers are using wearables to predict heart disease risk by tracking sleep, activity, and blood pressure. The $400K study targets early detection through daily data.

🌿 Brain Reset: Letting your mind wander, especially in nature, helps restore focus, ease stress, and sharpen thinking, says University of Lancashire research. Just 10 minutes of undirected attention boosts cognitive performance.

🪲 Aging Pause: Jewel wasps exposed to cold early in life slow their aging by 29%, University of Leicester scientists found. The chill-triggered delay adds over 33% to their adult lifespan.

🧫 Organ Upgrade: Scientists got lab-grown mini organs to grow their own blood vessels for the first time. This leap could fast-track drug testing, disease studies, and future tissue transplants.

💡 Biohack Bed: The $160K Ammortal Chamber blends 10 cutting-edge wellness tools—like red light, hydrogen therapy, and vibroacoustics—into one 30-minute session. Athletes and execs say it delivers instant calm, focus, and energy.

WHAT WE’RE BOOKMARKING

📱 Social

🎧 Podcasts

📰 Articles

⚙️ Tools to Try

Thanks for reading.

See you in the next issue.

Anna

DISCLAIMER: The information provided in this newsletter is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making any changes to your health or wellness routine.