Morning, long-lifers. Here’s what’s new:
Prenetics launches a supplement claiming to target all 12 hallmarks of aging - finally, something trying harder than your morning coffee.
If it actually works, your vitamins may start asking for a pension plan.
Don’t keep longer. a secret - share it with your friends!
This week in longevity:
🌍 How gravity shapes your gut, mood, and resilience
⏰ Can fasting help athletes age better?
🧠 Poor sleep may speed up brain aging
☀️ Vitamin B3 cuts skin cancer risk by 54%
🇫🇮 Finland’s new Blue Zone contender emerges
Plus, more longevity breakthroughs.
Read time: 5 minutes
THIS WEEK IN LONGEVITY
🌍 How Gravity Shapes Your Gut, Mood & Longevity
Source: Midjourney | longer.
We think of gravity as something that keeps us from floating away, but it may also help keep our guts, brains, and moods in line. A new idea called biogravitational medicine suggests that how well we adapt to gravity could shape our digestion, posture, and even emotional resilience. It’s not just about standing tall, it’s about living well under pressure.
What to know:
What it is: Biogravitational medicine studies how the body interacts with gravity and how that affects organs, circulation, digestion, and mood. Every cell evolved to function under this force, yet medicine has mostly ignored it.
Gut connection: For people with flexible joints or connective tissue issues, intestines can “sag” under gravity, leading to bloating or pain. Core exercises and proper breathing can help support these internal structures.
Mind-body link: Serotonin (a mood-regulating chemical mostly made in the gut) helps the body manage blood flow and digestion against gravity’s pull. A balanced microbiome supports this process.
Gravity intolerance: Symptoms like dizziness, bloating when upright, ankle swelling, or fatigue may signal trouble adapting to gravity.
Building resilience: Gravity-friendly habits include strength training, balance work such as standing on one foot, and mental practices such as breathwork or CBT to handle the “mental weight” of stress.
Why it matters: Gravity shapes more than posture. Supporting strength, balance, and digestion may boost long-term health and mental steadiness. Real resilience starts from the ground up.
What this means in practice: Train your core, practice balance, and eat for gut health. Sometimes the smartest health move is simply standing taller.
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Source: Viome
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⏰ Can Fasting Help Athletes Age Better?
Source: Midjourney | longer.
A new review of 18 studies suggests that time-restricted eating (TRE), where you eat all your meals within a set daily window, may help athletes manage body fat and inflammation without hurting performance. Early signs even hint that it could nudge the body’s “cell-cleaning” systems linked to healthy aging. The catch is that most of the evidence comes from short, small trials.
What to know:
What it is: Time-restricted eating (TRE) means eating within a set period each day, usually 8 to 12 hours, and fasting the rest. It focuses on when you eat, not necessarily what you eat.
Performance impact: Across studies lasting 3 to 98 days, athletes generally maintained or slightly improved performance while reducing fat mass. Elite cyclists in one 4-week trial improved power-to-weight ratio with stable muscle mass.
Cell-level signals: One very short study in non-athletes showed increased activity of SIRT1 and LC3A (genes linked to cellular repair and autophagy, the body’s clean-up system). These results are promising but not proof of slower aging.
Metabolic effects: TRE helped smooth blood sugar swings, improve fat burning, and reduce inflammatory markers. It also shifted hormone patterns that regulate hunger, fullness, and stress.
Evidence gaps: Only 4 of the 18 studies focused on athletes. Most trials were small and short, so claims about anti-aging remain early-stage and not clinically proven.
Why it matters: Eating within a shorter window may help athletes stay lean, lower inflammation, and support long-term health. The “longevity” idea is still just a theory, but the metabolic perks are hard to ignore.
What this means in practice: Try an 8 to 12 hour eating window that fits your training, and keep meals nutrient-dense. Skip late-night snacking. Eating smarter might simply mean eating earlier.
💡 Want to break down a research article? Try this prompt in ChatGPT:
“Explain this in plain language. Avoid science terms. Keep it under 5 sentences. Then give 5 takeaways based only on this summary—no extra info or guesses: [Paste the article here]”
MONEY MOVES IN LONGEVITY
💰 Heidi Health raises $65M Series B led by Point72, freeing doctors from paperwork one note at a time.
💰 Personal Health Tech raises ¥300M Series A extension for Kensapo; corporate health gets a data-driven boost.
💰 The Cat Health Company secures $1.2M to advance feline longevity drugs; longer nine lives backed by science.
💰 Algen Biotechnologies lands $555M AstraZeneca deal; CRISPR meets AI to decode aging at its roots.
IN THE SPOTLIGHT
Source: Midjourney | longer.
1. Poor Sleep May Speed Up Brain Aging
A huge MRI study of 27,500 adults found that worse sleep was linked to brains looking up to a year older. Inflammation explained part of the effect. Since sleep is fixable, this suggests better rest might literally keep your brain younger. Tonight’s early bedtime just got a scientific upgrade.
2. Vitamin B3 Supplement Slashes Skin Cancer Risk
A study of 33,000 VA patients found that nicotinamide, a form of vitamin B3, cut repeat skin cancer risk by up to 54%. That’s a big leap from earlier trials. Safe, cheap, and over the counter, it’s rare for cancer prevention to come in a pill bottle this ordinary.
3. Tuning Mitochondria for a Longer Life
Worms lived longer when researchers slightly blocked calcium flow into mitochondria, triggering a mild stress response that boosted cleanup and energy efficiency. Early life took a hit, aging slowed. It’s a reminder that a little stress, at the right time, can make cells stronger, even as they grow old.
THE NEXT BIG THING
The Nordic Blue Zone Experiment
Source: Peak Visor
Researchers in Finland just found that Swedish-speaking Ostrobothnia may qualify as a new Blue Zone, a region where people live unusually long lives.
The area stands out for its mix of strong community ties, moderate activity, balanced diets, and low stress, echoing traits seen in Okinawa, Ikaria, and Sardinia. The goal: uncover how culture and lifestyle shape longevity beyond genetics.
Early sign of a new Blue Zone or coincidence of culture and geography?
WHAT ELSE YOU SHOULD KNOW THIS WEEK
Source: IM8 Health
🧠 Memory Boost: Italian scientists used gold nanoparticles to deliver lithium through a nasal spray in Alzheimer’s mice. It improved memory by 45% and cut brain tau proteins nearly in half.
🌿 CBD Calm: Augusta University scientists found that inhaled CBD reduced brain inflammation and boosted memory in Alzheimer’s mice. Treated mice explored twice as long and remembered objects far better than untreated ones.
🧬 Brain Clock: A massive Nature Aging study of 56,000 people uncovered 59 genetic sites tied to brain aging. High blood pressure and diabetes were found to cause faster brain aging.
🥦 Smart Eating: Omada Health launched Meal Map, an AI nutrition tool that rates meals by nutrient quality instead of calories. In early tests, it increased meal tracking and engagement among over 1,000 users.
💊 Aging Breakthrough: Prenetics’ IM8 launched Daily Ultimate Longevity, the first supplement claiming to target all 12 hallmarks of aging. The brand hit $6.6M monthly revenue and eyes $100M annual run rate within a year.
WHAT WE’RE BOOKMARKING
📱 Social
Omega-3s help muscles recover faster.
40% less soreness at 24h
30% less damage markers post-exerciseWith EPA/DHA, athletes maintained muscle strength and range of motion. Those on placebo lost up to 40% of muscle strength and 20% of range of motion.
— #Bryan Johnson (#@bryan_johnson)
1:19 PM • Oct 8, 2025
New study of skin finds NMN stands apart from other NAD+ precursors, elevating NAD+ and activating sirtuins, while increasing autophagy, mitochondrial activity & cell growth
— #David Sinclair (#@davidasinclair)
2:19 PM • Oct 4, 2025
🎧 Podcasts
📰 Articles
Magnesium prevents colon cancer, by increasing vitamin D synthesis.
~200 mg / day was shown to increase the bacteria:
➟ F. prausnitzii
➟ C. maltaromaticumwhich aid in the production of vitamin D within the gut, and prevent carcinogenesis in the colon.
— #Analyze & Optimize (#@Outdoctrination)
1:11 AM • Oct 6, 2025
⚙️ Tools to Try
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