Morning, long-lifers. Here’s what’s new:

“Pause” button for cell death could slow aging — your cells have been rage-quitting, and now science wants to calm them down.

They’re not dying quietly — they’re going full rockstar and trashing the joint on their way out.

Don’t keep longer. a secret—share it with your friends!

This week in longevity:

• 🧫 Zombie cell removal enters human trials

• 🌿 Rosemary shows real brain-boosting effects

• 🤖 Social robots help older adults thrive

• 👁️ Bionic vision lets monkeys see infrared

• 🧪 New gene reverses aging without cancer risk

• Plus, more longevity breakthroughs.

Read time: 5 minutes

THIS WEEK IN LONGEVITY

🛑 “Pause” button for cell death could slow aging

Stopping necrosis — a messy form of cell death — might be the next big move in aging science. A new study shows that blocking this internal “meltdown” could reduce inflammation, protect organs, and even help astronauts age more slowly. Turns out, dying cells aren’t just debris — they’re troublemakers.

What to know:

• Necrosis is uncontrolled cell death: Unlike programmed cell death (which helps your body stay healthy), necrosis is chaotic and damaging — cells burst, spill toxins, and trigger inflammation.

• Calcium kicks it off: A calcium flood short-circuits the cell, sending it into meltdown and harming nearby tissue.

• It accelerates aging: The study shows necrosis isn’t just the end of a cell — it actively drives aging and disease in organs like the heart, brain, and kidneys.

• Kidneys get hit hard: Necrosis fuels kidney decline, which affects nearly half of adults by age 75. Targeting it could slow this breakdown.

• Space makes it worse: Astronauts face faster necrosis-related damage from radiation and low gravity. Blocking it could protect them on long missions.

When cells die badly, they don’t just fade away — they start a fire your body has to put out.

Why it’s important: Stopping necrosis could buy our bodies more time — literally. Less inflammation, better organ function, and maybe even a shot at healthier aging or longer space travel. It’s like unplugging the smoke alarm before the toast burns the kitchen down.

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🩸 New blood test estimates how fast you’re really aging

A new study introduces a biological clock that predicts how fast your body is declining — using just a drop of blood or saliva. Built on DNA methylation data, this “IC clock” measures intrinsic capacity (your body’s total physical and mental reserves). It may beat older aging clocks at predicting how long you’ll live — or how well.

What to know:

• Intrinsic capacity = your body’s total reserve: It sums up five key areas — energy, thinking, movement, mood, and senses — to reflect how well your body and brain can handle daily life and stress as you age.

• Built from DNA methylation: Researchers analyzed over 1,000 people’s blood for DNA methylation (chemical tags that regulate genes) to predict IC. The result: a personalized score from 0 to 1.

• Stronger than older clocks: The IC clock outperformed other aging clocks like PhenoAge at predicting all-cause mortality — especially when drawn from blood or saliva.

• Linked to real biology: IC scores reflected deeper changes like immune aging, inflammation, mitochondrial function, and even how well your cells clean up damaged proteins (proteostasis).

• Lifestyle still matters: Eating fish rich in omega-3s and keeping sugar in check were the two strongest lifestyle predictors of better IC — even after controlling for other factors.

Why it’s important: This clock offers a practical way to measure how your body is aging — not just your calendar. That means more precise tracking of interventions, lifestyle changes, and maybe one day, drugs. And yes, it’s another reason your salad should probably have sardines in it.

💡 Want to break down a research article? Try this prompt in ChatGPT:
“Explain this in plain language. Avoid science terms. Keep it under 5 sentences. Then give 5 takeaways based only on this summary—no extra info or guesses: [Paste the article here]”

 MONEY MOVES IN LONGEVITY

💰 Juvena inks $650M drug discovery deal with Lilly — muscle meets money in the metabolic gold rush.

💰 Somnee raises $10M to launch AI sleep headband — melatonin’s out, brainwaves are in.

 IN THE SPOTLIGHT

1. Daily avocado linked to better sleep, new study finds
A six-month study found that eating one avocado a day improved sleep health, diet quality, and blood fats, even if heart scores stayed the same. Researchers were surprised—your favorite toast topping might be a small, tasty step to sleeping soundly, naturally.

2. Rosemary’s brain boost backed by new science
Studies show rosemary improves memory, reduces anxiety, and may protect against Alzheimer’s by preserving brain chemicals and calming inflammation. The magic might lie in diAcCA, a rosemary compound that targets inflamed brain regions—promising results, no mouse complaints.

3. Lift before you run to burn more fat, study says
New research shows doing weights before cardio leads to more fat loss, more strength, and more daily movement than cardio-first workouts. Think of it as draining your sugar tank so your body has to burn fat for fuel—science-backed and sweat-approved.

THE NEXT BIG THING

Longevity Science Meets Home Design

Ultrahuman just launched a $549 device that monitors air, light, noise, and more—linking your environment to recovery, sleep, and performance.

It connects indoor factors like CO₂ and blue light to real health outcomes: circadian rhythm, cognition, even mortality risk.

Your home could be affecting you more than your DNA.

And now, for the first time, you can measure it.

WHAT ELSE YOU SHOULD KNOW THIS WEEK

🧬 Birth Window: Italian scientists discovered a brief post-birth window to deliver gene therapy directly into newborns’ blood stem cells. This could treat immune and bone diseases—no transplant or chemo needed.

🤖 Aging Ally: UK researchers found that socially assistive robots can boost independence and emotional well-being in older adults. When designed with empathy, these robots reduce mental strain and enhance daily life.

👁️ Nano Vision: Scientists restored sight in blind mice using a retinal implant made of light-sensitive nanowires. It even let monkeys see infrared—paving the way for next-gen bionic vision.

🧪 Cell Cleanup: Rubedo launched the first human trial of a drug that targets aging skin by removing toxic “zombie” cells. The treatment aims to reduce inflammation and slow visible aging.

🧫 Gene Reset: UK biotech Shift Bioscience found a single gene, SB000, that reverses cell aging without cancer risk. It matches Yamanaka factors in power—without making cells go rogue.

WHAT WE’RE BOOKMARKING

📱 Social

🎧 Podcasts

📰 Articles

⚙️ Tools to Try

Thanks for reading.

See you in the next issue.

Anna

DISCLAIMER: The information provided in this newsletter is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making any changes to your health or wellness routine.