Morning, long-lifers. Here’s what’s new:

This AI eye scan knows your age and heart risk — just by staring into your soul.

Finally, a judgmental stare that comes with medical insights and not just passive —aggressive energy from your aunt. Your pupils might dilate from the news alone.

Don’t keep longer. a secret - share it with your friends!

This week in longevity:

• 🧠 Creatine may help fix damaged brains

• 💊 Pill mimics exercise without heart side effects

• 🍄 Psilocybin extends mouse lifespan 30%

• 🧬 Gene-edited mice lose weight on autopilot

• 🥦 Copper intake linked to better memory

• Plus, more longevity breakthroughs.

Read time: 5 minutes

THIS WEEK IN LONGEVITY

👁️‍🗨️ This AI eye scan estimates your real age and your heart risk

A new AI tool called BioAge™ uses a single retinal image to estimate how fast you’re aging and how at-risk your heart might be — no needles, no stress test, just a photo of your eye. It’s already available as a wellness tool in the U.S., and a medical-grade version called CLAiR™ is fast-tracked for FDA approval. The science? Your eyes really are a window to your health.

What to know:

• Reads aging in your retina: BioAge™ estimates biological age (how old your body acts, not just your birthday) by analyzing tiny blood vessels and patterns in the eye.

• Also flags heart disease risk: CLAiR™, their upcoming platform, uses the same retinal image to assess cardiovascular risk — with no blood draw or scan required.

• FDA sees promise: CLAiR™ earned Breakthrough Device status, putting it on a fast-track for approval due to its potential to improve early diagnosis of heart disease.

• Non-invasive and fast: All it takes is a retinal photo - the same kind you’d get during a routine eye exam - and the AI delivers insights in seconds.

• Built for real-world use: It’s already being used in wellness settings, and once approved, could be added to clinics, pharmacies, and even mobile screenings.

Why it’s important: Heart disease and aging often sneak up quietly. This tool catches signs early — before symptoms show up — and without the usual friction of medical testing. It’s like a crystal ball for your health, hiding in the back of your eye.

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🧠 Creatine isn’t just for muscles — it may help repair the brain

Virginia Tech scientists are testing a way to get creatine — the popular workout supplement — into the brain using focused ultrasound. While creatine helps fuel muscles, it’s also essential for brain function. The problem? It doesn’t easily cross the blood-brain barrier. This new method could open the door to treating serious neurological conditions caused by creatine deficiency.

What to know:

• Creatine fuels brain energy: It helps produce ATP (the energy currency of cells) and supports brain areas tied to learning, memory, and seizure control.

• Blocked by the brain’s defenses: The blood-brain barrier keeps toxins out — but it also prevents helpful compounds like creatine from getting in when they’re needed most.

• Ultrasound as a delivery tool: Researchers use focused sound waves to temporarily open small areas of the brain, allowing creatine to cross through safely.

• Inspired by brain cancer research: The method was first tested to treat pediatric brain tumors — now it’s being adapted for metabolic disorders like creatine transporter deficiency.

• Restoring brain growth: Early lab models will test whether the technique can restore brain mass and function in people with creatine-related developmental issues.

Why it’s important: Creatine supplements bulk up muscle — but for some kids, the real goal is rebuilding brain tissue and restoring speech and learning abilities. One day, a workout supplement might quietly rewrite the rules of brain repair.

💡 Want to break down a research article? Try this prompt in ChatGPT:
“Explain this in plain language. Avoid science terms. Keep it under 5 sentences. Then give 5 takeaways based only on this summary—no extra info or guesses: [Paste the article here]”

 MONEY MOVES IN LONGEVITY

💰 Vie Ventures launches with $75M target to back autoimmune biotechs — where VC meets mission-driven muscle

💰 Sensifai Health raises seed round led by Glen Ventures to detect illness before symptoms — AI meets the immune system’s whisper.

 IN THE SPOTLIGHT

1. Psilocybin extends lifespan in mice and human cells
A new Emory study found psilocybin boosted human cell lifespan by 50% and aged mice lived 30% longer with better health. Researchers link it to reduced stress and better DNA repair. Psychedelic mushrooms may do more than shift your mind - they might slow the clock too.

2. Adult brains may still grow new neurons
A new study found rare stem cells in adult hippocampi, suggesting neurogenesis can continue into old age. Some brains showed more growth than others. Your brain might not be done yet — even in your seventies, it could still be planting new mental seeds.

3. Blueprint unveiled for longevity testing in mice
A new protocol standardizes how biotech firms can test drug effects on mouse lifespan, potentially revealing hidden long-term risks or anti-aging benefits. Think of it as a user manual for stress-testing tomorrow’s drugs before they hit human trials — a rare blend of rigor, realism, and ROI.

THE NEXT BIG THING

A Clinic for Living Longer?

Northwestern Medicine just opened a new clinic — not for treating illness, but for slowing aging.

The Human Longevity Clinic offers personalized testing to assess how each person is aging, then maps out lifestyle changes to help “bend the curve.”

Tests cover brain function, heart, lungs, muscles, and blood biomarkers. Patients get retinal imaging and meet with a doctor, a dietitian, and an exercise physiologist to review their results.

Located in downtown Chicago, the clinic retests patients after six months to track progress.

WHAT ELSE YOU SHOULD KNOW THIS WEEK

🧠 Brain Clock: Stanford researchers found brain ageing predicts longevity better than any other organ. A fast-ageing brain raises all-cause death risk by 182% over 15 years.

💊 Muscle Boost: Swedish biotech Atrogi’s new pill ATR-258 mimics exercise, preserving muscle while cutting fat. It reverses GLP-1-linked muscle loss without triggering heart side effects.

🧫 Aging Signals: New research links skin cell biomarkers to real-world physical ability in aging adults. Periostin, a tissue-repair protein, emerged as a top predictor of functional decline.

🧬 Gene Slim: Osaka researchers used genome editing to make mice produce their own weight-loss drug, Exenatide. One treatment cut weight gain and improved metabolism for months.

🥦 Copper Brain: A U.S. study linked higher copper intake (1.22–1.63 mg/day) to better memory and thinking in older adults. Stroke survivors saw the biggest cognitive boost from more copper.

WHAT WE’RE BOOKMARKING

📱 Social

🎧 Podcasts

📰 Articles

⚙️ Tools to Try

Thanks for reading.

See you in the next issue.

Anna

DISCLAIMER: The information provided in this newsletter is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making any changes to your health or wellness routine.