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Fasting for 24 hours can spike human growth hormone levels by up to 1,225%—proving that skipping meals might just be the easiest way to biohack your body.

Looks like your stomach’s growls might actually be cheering you on.

Don’t keep longer. a secret—share it with your friends!

This week in longevity:

• 💪 Scientists discover key to reversing muscle aging

• 🧠 AI tool detects hidden heart disease risk in women

• 🥦 Microgreens pack more nutrients than mature vegetables

• 🚀 Space agencies explore biotech to keep astronauts healthier

• 🛌 Biohacker claims sleep and red light therapy reversed aging

• Plus, more longevity breakthroughs.

Read time: 5 minutes

THIS WEEK IN LONGEVITY

FEATURED

🚰 24-Hour Water Fast Boosts Key Growth Hormone—No Diet Needed

A new study from Frontiers in Endocrinology found that fasting for just 24 hours can dramatically increase human growth hormone (HGH), a hormone that helps with muscle growth, metabolism, and recovery. Surprisingly, this boost happens even without weight loss—especially in people with naturally low HGH levels.

What to know:

• Fasting triggered a huge HGH increase—People with low HGH saw their levels rise by up to 1,225% in just 24 hours.

• No weight loss needed—Unlike other HGH-boosting methods, this effect happened even when body weight stayed the same.

• Women had the strongest response—Female participants with low HGH levels saw a much bigger increase than men.

• Body switches to fat-burning—After 20+ hours without food, the body stops using sugar for energy and starts burning fat instead.

• Could improve metabolism—Higher HGH levels may help the body process energy better, but more research is needed on long-term effects.

Why it’s important: HGH plays a key role in muscle recovery, fat burning, and metabolism. This study suggests that even a short fast could naturally boost HGH—without extreme diets or intense workouts. If future research confirms the benefits, fasting could be a simple way to support overall health.

FEATURED

💪 Scientists Discover Key to Reversing Muscle Aging

A new study from the University of Ottawa has uncovered a major breakthrough in muscle aging. Researchers identified an enzyme called GCN5 that plays a crucial role in keeping muscles strong. Without it, muscles struggle to recover from physical stress—just like in aging and muscle diseases. This discovery could lead to new therapies for conditions like muscular dystrophy, cancer-related muscle loss, and age-related weakness.

What to know:

• GCN5 is essential for muscle strength—It’s an enzyme that helps muscles produce important proteins, keeping them strong and resistant to damage.

• Without GCN5, muscles break down—Researchers tested genetically modified mice missing GCN5, and their muscles became weak, mimicking aging effects.

• Key protein dystrophin depends on GCN5—Dystrophin is a protein that protects muscles from damage, but without GCN5, it disappears.

• Potential for new treatments—If scientists can find a way to boost GCN5, they might be able to slow or even reverse muscle loss from aging or disease.

Why it’s important: Muscle loss is a major challenge as people age, making everyday movements harder. If future treatments can activate GCN5, they could help people stay stronger, prevent muscle-related diseases, and improve overall health.

💡Pro Tip: Want to dive deeper? Use tools like ChatGPT, Claude, or Grok to simplify complex studies. Copy, paste, and get a clear summary—it’s like having a personal research assistant.

IN THE SPOTLIGHT

1. Lifestyle Has a Bigger Impact on Longevity Than Genetics
Your daily habits matter more than your DNA when it comes to living longer. Researchers found that environmental factors like smoking, income, and exercise influence disease risk far more than genetics. Even childhood exposures, like maternal smoking or early-life weight, can have lasting effects—proving that the choices you make can shape your lifespan.

2. Startup Subsense Unveils Noninvasive Brain-Computer Interface
Neurotech startup Subsense has raised $17 million to develop a brain-computer interface (BCI) that doesn’t require surgery. Unlike existing BCIs, which need implanted sensors, Subsense uses biocompatible nanoparticles that act as “antennae” to transmit and receive neural signals. This approach could make BCI technology safer and more accessible, with potential applications in treating neurological diseases, restoring motor functions, and even enhancing human cognition.

3. New AI Tool Detects Hidden Heart Disease Risk in Women
Researchers at Imperial College London have developed an AI tool that can detect heart disease risk in women using a simple ECG. The model flags high-risk patients by analyzing how closely their heart’s electrical patterns match typical male or female ECGs. Many women at risk go undiagnosed, but this breakthrough could help close the gender gap in heart care and improve early detection.

LONGEVITY SNAPSHOTS

WHAT ELSE YOU SHOULD KNOW THIS WEEK

🦠 Longevity Everywhere: Biotech that slows aging could reshape industries far beyond medicine, from pollution cleanup to military performance. Even space agencies are eyeing these innovations to keep astronauts healthier on deep-space missions.

🥦 Microgreen Power: Microgreens pack more vitamins, minerals, and antioxidants than mature vegetables. Black radish leads in antioxidants, while bean microgreens deliver the highest vitamin C boost.

😃 Optimism Wins: Optimism boosts resilience, lowers stress, and improves well-being. Interestingly, lower pessimism—not higher optimism—led to safer health behaviors.

🧠 Alzheimer’s Breakthrough: Compounds that boost SIRT1, a key brain-protecting enzyme, could help fight Alzheimer’s. Natural compounds like resveratrol and new pharmaceuticals show promise in slowing memory loss and neurodegeneration.

🛌 Sleep & Light: A longevity clinic owner claims biohacking reversed her biological age by 11 years. Her top hacks? Prioritizing eight hours of sleep and daily red light therapy to boost energy and skin health.

LONGEVITY LAB

LONGEVITY LAB

How AI is Revolutionizing Full-Body MRI

Prenuvo is changing preventative healthcare with full-body MRI scans that detect diseases early.

Their AI-driven technology captures over a billion data points in under an hour, offering deeper insights than traditional imaging.

With $120M in funding and FDA clearance for their Body Composition report, Prenuvo is expanding into brain health scans to catch cognitive decline sooner.

Will AI-driven imaging become the new standard in healthcare—or remain a luxury option?

WHAT WE’RE BOOKMARKING

📱 Social

🎧 Podcasts

• “How to Lose Weight, Lower Inflammation, Overcome Hormone Imbalances and Ozempic’s Bad PR with Dr. Tyna Moore” – Arielle Lorre, Well with Arielle Lorre: A deep dive into GLP-1s, metabolic health, and what we’re getting wrong about Ozempic (Apple Podcast link).

• “Your Gut Controls Your Mood, Cravings, and Even Personality w/ Dr. Gundry” – Ed Mylett, The Ed Mylett Show: A deep dive into how your gut microbiome influences your thoughts, cravings, and mental health (Apple Podcast link).

📚 Books

• “The Longevity Leap” by Siim Land: A science-backed guide to slowing aging and adding healthy years to your life (Amazon link).

⚙️ Tools to Try

• Withings Smart Scales: Next-level health tracking with precision body composition insights and even an ECG option (Product website).

Thanks for reading.

See you in the next issue.

Anna

DISCLAIMER: The information provided in this newsletter is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making any changes to your health or wellness routine.