Your weekly longevity insights are here.

AI finds genes behind brain aging—and drugs to slow it — Turns out your brain might be older than you, which explains why it forgot your Netflix password again.

But hey, at least it might age better on hydrocortisone and red wine.

Don’t keep longer. a secret—share it with your friends!

This week in longevity:

• 🏋️‍♀️ Jump training helps women age strong

• 🔬 Amino acid shows anti-aging promise

• 🔊 Ultrasound makes old cells act young again

• 🧪 Supplement drops biological age by 5.7 years

• 🧴 Skincare shifts to pro-longevity focus

• Plus, more longevity breakthroughs

Read time: 5 minutes

THIS WEEK IN LONGEVITY

FEATURED

🧠 AI finds genes behind brain aging—and drugs to slow it

A massive AI study analyzed brain scans from nearly 39,000 people and found genes linked to how fast (or slow) our brains age. The researchers also spotted 28 existing drugs that might help slow brain aging—some of them already on pharmacy shelves. It’s one of the largest studies ever to connect brain scans, genetics, and real medications that could one day keep minds sharper, longer.

What to know:

• Brain aging ≠ birthday candles: Your brain has its own “biological age,” which doesn’t always match your actual age. Some people’s brains age faster, while others stay younger longer.

• AI meets brain scans: Researchers used advanced AI models to analyze brain MRIs and detect patterns linked to aging in the brain’s structure.

• Two key brain regions stand out: The lentiform nucleus (involved in movement and emotion) and a neural “highway” used for thinking and decision-making were major clues to brain aging speed.

• Seven aging-linked genes found: Some control brain wiring, fight inflammation, or remove damaged cells—all important for healthy brain aging.

• 28 existing drugs could help: These include hydrocortisone (often used for allergies), resveratrol (found in red wine), and even testosterone. Because they’re already approved, testing them for brain aging could happen faster.

Why it’s important: This kind of research could lead to treatments that keep your brain younger for longer—without waiting decades for brand-new drugs. It also shows how AI and huge health databases can unlock real-world ways to boost brain health as we age.

FEATURED

🧬 Your liver and immune system might have a reset button

Biotech startup NewLimit has found a way to make old liver and immune cells act young again. By using epigenetic reprogramming—a method that resets how genes behave without changing your DNA—they restored youthful function in lab models of liver disease and immune aging. It’s still early, but this could lead to powerful new therapies that tackle aging at the cellular level.

What to know:

• Reprogramming cells: NewLimit used transcription factors (proteins that control gene activity) to reboot old cells and restore their function.

• Liver cells bounce back: In mice with liver damage, treated liver cells regenerated better and showed near-youthful resilience after injury.

• Immune system upgrade: Aged T cells—essential for fighting infection and cancer—regained their killing power after reprogramming.

• AI meets cell biology: The team used single-cell genomics and machine learning to find the most effective gene-resetting combinations.

• What’s next: These results are still pre-clinical, but NewLimit aims to turn them into mRNA-based medicines for aging-related conditions.

Why it’s important: Instead of treating the effects of aging, this approach targets the root: tired, dysfunctional cells. If it works in humans, it could mean stronger immune systems and healthier organs—well into old age.

💡Pro Tip: Want to dive deeper? Use tools like ChatGPT, Claude, or Grok to simplify complex studies. Copy, paste, and get a clear summary—it’s like having a personal research assistant.

IN THE SPOTLIGHT

1. Ultrasound That Turns Back the Clock on Aging Cells
Researchers have discovered that low-frequency ultrasound can reverse cellular senescence, restoring aged cells to a more youthful, functional state. Unlike drugs that merely slow senescence, this physical treatment revived cell growth, boosted energy activity, and erased aging markers in lab and animal models. Mice treated with ultrasound even lived significantly longer, opening a new frontier in non-invasive anti-aging therapies.

2. Jump Training Tops List of Best Longevity Workouts for Women
Dr. Stacy Sims says jump training—short bursts of explosive movement—is one of the most effective ways women can build strength, protect their bones, and stay independent as they age. It’s safe, powerful, and takes just 10 minutes a few times a week. Combined with sprint intervals, heavy lifting, and high protein, it forms a science-backed formula for aging strong.

3. This Little-Known Amino Acid Could Help Fight Aging and Inflammation
Researchers found that levels of citrulline—a natural amino acid—drop as we age, which may drive chronic inflammation and other signs of aging. In mice, long-term citrulline supplements reduced inflammation, improved cell health, and even helped rebalance the immune system. It also naturally blocked mTOR, a key aging pathway, making citrulline a promising new tool in the longevity toolbox.

LONGEVITY LAB

THE NEXT BIG THING

Can a Supplement Turn Back the Clock?

A new 12-month study says yes—at least on a cellular level.

SRW’s Cel System, a trio of supplements made from polyphenols, antioxidants, vitamins, and minerals, was tested in healthy adults aged 54 to 84. After one year, participants saw an average 5.71-year drop in biological age, alongside gains in grip strength, waist reduction, and immune function.

The study used multiple epigenetic clocks and physiological tests, making it one of the more comprehensive supplement trials to date.

LONGEVITY SNAPSHOTS

WHAT ELSE YOU SHOULD KNOW THIS WEEK

🥦 Aging Advantage: A 30-year study of 100,000 U.S. adults found diets rich in whole, unprocessed foods boost healthy aging. The top-scoring diet raised the odds by up to 124%.

🥓 Keto Rewind: A strict (very) low-calorie keto diet reversed biological aging by over six years in obese adults. The age slowdown tracked with weight loss, better metabolism, and ketone levels (energy molecules from fat).

🧠 Memory Plumbing: WashU scientists restored memory in aging mice by fixing brain-adjacent vessels that drain waste. The treatment also reduced inflammation and rewired brain signaling.

🧴 Skin Shift: Mayo Clinic says skincare is moving from “anti-aging” to “pro-longevity,” prioritizing lifelong skin health. Think sunscreen, antioxidants, retinol—and even 3D bioprinted skin.

🏥 Luxe Longevity: Whole Foods founder John Mackey launched Love.Life, a $50,000-a-year clinic with VO2 max tests, red light therapy, and hyperbaric chambers. Members get personalized plans, labs, and daily recovery treatments.

WHAT WE’RE BOOKMARKING

📱 Social

🎧 Podcasts

📰 Articles

⚙️ Tools to Try

Thanks for reading.

See you in the next issue.

Anna

DISCLAIMER: The information provided in this newsletter is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making any changes to your health or wellness routine.