Morning, long-lifers. Here’s what’s new:

Young blood revives aging skin - science found the proteins that make old cells act young.

Turns out your skin just needed a little youth serum — minus the fangs and capes.

Don’t keep longer. a secret - share it with your friends!

This week in longevity:

• 🐕 Dog anti-aging pill nears FDA approval

• 🧠 Pomegranate compound sparks brain cell repair

• 🌙 Night light linked to weaker immunity

• 🚶‍♂️ Faster walking slashes heart and stroke risk

• 💊 Metformin still leading anti-aging drug race

• Plus, more longevity breakthroughs.

Read time: 5 minutes

THIS WEEK IN LONGEVITY

🩸 Young blood revives aging skin — literally

Researchers used a high-tech 3D skin system to show that proteins from young blood can help aging skin cells act younger. But the trick isn’t just in the blood — it’s the bone marrow behind it. Turns out, the vampire legends weren’t entirely off... they just needed a microfluidic chip.

What to know:

• Young blood triggers skin repair: Scientists used blood serum from people under 30 and found it boosted skin cell regeneration and mitochondrial function (your cells’ energy production).

• Bone marrow matters: The effect only happened when bone marrow cells were present — they’re the ones secreting the actual skin-rejuvenating proteins.

• 55 proteins ID’d, 7 did the magic: Of the 55 proteins released, 7 were key to making old skin cells behave like younger ones.

• New testing tech made it possible: Researchers used a “microphysiological system” (a lab-on-a-chip that mimics human organs) to simulate how young blood interacts with skin and bone marrow.

• Could reshape anti-aging products: This research points to the potential for skin creams that include lab-grown versions of these proteins — minus the blood bags.

Why it’s important: This study moves anti-aging beyond hype, showing real cellular rejuvenation. If confirmed, it could lead to biotech-powered skincare — no vampires needed.

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💉 Is GLP-1 microdosing a smarter way to lose weight?

A growing number of people are using lower-than-standard doses of GLP-1 drugs (like Ozempic or Wegovy) to manage weight. Platforms like Noom now offer microdosing programs claiming fewer side effects and lower costs. But experts say: proceed with caution — and a doctor.

What to know:

• Microdosing means much smaller doses: Programs like Noom start GLP-1 dosing at just 25% or less of the standard starting amount, adjusting slowly based on how your body responds.

• It’s not new to doctors: Many obesity specialists already adjust GLP-1 dosing this way to minimize side effects like nausea, fatigue, or GI issues.

• Still experimental: There are no published studies yet on microdosing GLP-1s, and compounded meds (often used in these programs) aren’t FDA-approved.

• Effectiveness varies: Some people see benefits at low doses, especially for weight maintenance. But others may need full-strength meds for real weight loss.

• Safety depends on sourcing: Compounded versions can help with affordability — but quality depends on the pharmacy. Medical oversight is critical.

Why it’s important: For many, GLP-1s are too pricey or too intense. Microdosing might offer a middle ground — but it’s not magic, and it’s not for everyone.

💡 Want to break down a research article? Try this prompt in ChatGPT:
“Explain this in plain language. Avoid science terms. Keep it under 5 sentences. Then give 5 takeaways based only on this summary—no extra info or guesses: [Paste the article here]”

 MONEY MOVES IN LONGEVITY

💰 Sanofi completes $470M Vigil Neuroscience buy, adding Alzheimer’s hopeful VG-3927 to its neurology bench.

💰 Fountain Life raises $18M Series B, expanding early-detection longevity clinics from Robbins and Diamandis.

💰 Gameto raises $44M Series C, pushing Fertilo to finish line and fast-tracking menopause fix Ameno.

💰 Chai Discovery nets $70M Series A, using AI to design new antibodies in weeks instead of years.

💰 Jocasta Neuroscience lands $35M Series A, aiming to slow dementia’s fade with a brain-boosting protein.

 IN THE SPOTLIGHT

1. Urolithin A shows promise for brain health
Animal studies link this pomegranate-derived molecule to better mitochondria and less inflammation in brain cells. Human trials show it’s safe and gene-activating. It’s not a miracle, but it’s the first to spark mitochondrial repair in people without side effects.

2. Youthful matrix revives old stem cells
Aged stem cells grown in a mix made from birth tissue proteins had more energy, aged slower, and functioned better. Even their mitochondria improved. Turns out, environment really is everything — even for your cells.

3. Nighttime light quietly harms your health
Studies show that evening light weakens immunity, inflames the brain, and disrupts metabolism. Mood and sleep also take a serious hit. Screens, streetlights, and hospital bulbs may be doing more damage than you think.

THE NEXT BIG THING

Dog longevity pills are coming

Loyal has raised $135 million to develop veterinary drugs that slow canine aging, with its first FDA conditional approval expected next year.

The startup is targeting metabolic slowdown in senior dogs, growth hormone reduction in large breeds, and affordable monthly pricing under $150.

The goal: give dogs extra healthy years with their families.

Early sign of a new pet health era or just wishful thinking?

WHAT ELSE YOU SHOULD KNOW THIS WEEK

🧬 Immune Age: Omniscope's new osLongevity platform tracks aging by decoding immune cells with AI. It shows real-time shifts in immune health from diet, exercise, or illness.

🦠 Aging Trigger: A major review finds that lifelong infections like herpes and toxoplasma can hijack human cells and speed up aging. These microbes disrupt immune signals, shorten telomeres, and fuel Alzheimer’s-linked brain changes.

🚶‍♂️ Step Power: Walking just 3,000 steps a day at a faster pace cuts heart disease risk by 17% in people with high blood pressure. Every 1,000 extra steps slashes stroke risk by 25%.

💊 Metformin Momentum: Longevity expert Dr. Nir Barzilai says metformin’s anti-aging benefits keep growing, despite some recent critiques. It hits more aging hallmarks than any other drug and may soon reshape healthcare.

🧑‍⚕️ Clinical Pivot: The first Global Longevity Summit this October will unite top scientists and doctors to bring longevity into real-world care. The goal: replace hype with science and train physicians in evidence-based aging care.

WHAT WE’RE BOOKMARKING

📱 Social

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⚙️ Tools to Try

Thanks for reading.

See you in the next issue.

Anna

DISCLAIMER: The information provided in this newsletter is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before making any changes to your health or wellness routine.