Morning, long-lifers. Here’s what’s new:
Brain training rewinds brain chemistry by a decade - turns out your tablet might be better at anti-aging than your skincare routine.
At this rate, Sudoku could qualify for continuing medical education credits.
Don’t keep longer. a secret - share it with your friends!
This week in longevity:
💪 Midlife grip strength predicts future health
🧠 Oxytocin combo extends lifespan by 70% in males
🍎 Urolithin A tames inflammatory “zombie” cells
🔋 FDA approves first mitochondrial-boosting drug
💊 Swiss luxury wellness lands at Bergdorf Goodman
Plus, more longevity breakthroughs.
Read time: 5 minutes
THIS WEEK IN LONGEVITY
🧩 Brain training rewinds brain chemistry by a decade
Source: Midjourney | longer.
“Brain games” have long been the snack food of neuroscience: fun, but not exactly nourishing. Now, researchers at McGill’s Neuro Institute found that 10 weeks of targeted digital brain training can restore a key brain chemical, acetylcholine (needed for focus and memory), to levels seen in people ten years younger. No drugs required, just consistency and clicks.
What to know:
The study: 92 adults over 65 trained daily on the BrainHQ app for 10 weeks. Only that group showed restored acetylcholine activity on brain scans.
Why it matters: Acetylcholine is the chemical that keeps neurons talking. It declines with age and drops fast in Alzheimer’s.
The method: A special brain scan measured this chemical directly, confirming real neurochemical change.
The difference: These aren’t trivia games. The exercises adapt to your performance to drive neuroplasticity (the brain’s ability to rewire itself).
The shift: It’s the first human proof that training, not medication, can rejuvenate brain chemistry.
Why it matters: This suggests cognitive aging isn’t fixed. It can be trained back toward youth. If this holds true, your most powerful anti-aging tool might already be on your tablet.
Do short, structured mental workouts each day that challenge speed and focus. Think of it as brain interval training. Quick, focused sessions that help keep your mind sharp and chemistry young.
MADE POSSIBLE BY PROLON
⏳ Your body needs a break — but your schedule won’t give it one.
Source: Prolon
Prolon’s 5-day nutrition program mimics fasting without the hunger — helping you reset metabolism, support longevity, and feel in control again.
Clinically proven. Backed by 25+ years of research. Validated in 37 trials across 18 world-class institutions.
💪 Your midlife grip predicts your future health
Source: Midjourney | longer.
How hard you can squeeze may say more about your future than a blood test. A massive UK study of 93,000 adults found that people with stronger handgrips in their 40s to 60s were far less likely to develop obesity-related diseases or die early over the next 13 years. Basically, stronger hands meant longer, healthier lives.
What to know:
The study: 93,275 adults aged 40–69 were tracked for 13 years. Stronger grip strength in midlife predicted fewer health problems and lower death rates.
The link: Every 11.6 kilograms of extra grip strength lowered the risk of developing a first health issue by 14% and the risk of death by 13%.
The numbers: Protective grip strength thresholds were about 32 kilograms to avoid early problems, 39 kilograms to slow disease progression, and 47 kilograms to lower mortality risk.
Why it works: Grip strength reflects total muscle quality. More muscle means lower inflammation, better blood sugar control, and healthier metabolism.
The takeaway: Muscle strength appears to shield the body long before disease symptoms appear, even in people carrying extra weight.
Why it matters: This turns “strong for your age” into more than a compliment. Your grip may be a simple, cheap way to spot metabolic decline years before it shows up in bloodwork. Sometimes the future of health looks a lot like a squeeze test.
What this means in practice: Start strength training in midlife, aiming to challenge large muscle groups a few times a week. Even basic resistance bands or dumbbell work helps. The rule of thumb: keep your muscles doing something useful, and your metabolism will likely return the favor.
💡 Want to break down a research article? Try this prompt in ChatGPT:
“Explain this in plain language. Avoid science terms. Keep it under 5 sentences. Then give 5 takeaways based only on this summary—no extra info or guesses: [Paste the article here]”
MONEY MOVES IN LONGEVITY
💰 TruDiagnostic wins $400K NIH SBIR grant to build dynamic DNA methylation model, mapping change in real time.
💰 Oura raises $900M led by Fidelity at $11B valuation, tightening its ring on the health-tech market.
💰 Bevel raises $10M from a single investor, sharpening its edge in health and longevity tracking.
💰 Kneu Health secures $5.6M seed co-led by Oxford Science and Cedars-Sinai, dialing neurology into daily life.
IN THE SPOTLIGHT
Source: Midjourney | longer.
1. Hormone Combo Dramatically Extends Lifespan
A mix of oxytocin and an Alk5 inhibitor boosted lifespan by over 70% and restored vitality in older males. Females saw limited effects. Aging research is getting personal, showing that the path to lasting health and longevity may differ for men and women.
2. Urolithin A Calms Aging Cells
Researchers found that Urolithin A, a gut-derived compound from pomegranates and nuts, reduces inflammation by quieting senescent cells that drive aging. It doesn’t kill these “zombie cells.” It teaches them to behave, turning fiery old cells into quieter neighbors for healthier aging.
3. FDA Approves First Mitochondrial Drug
Elamipretide, once called SS-31, was approved to help people with Barth syndrome build muscle strength. It works by improving cell energy. It’s an early but exciting sign that boosting our cells’ power plants might one day help everyone age a little better.
THE NEXT BIG THING
Longevity luxury hits Bergdorf Goodman
Source: Clinique La Prairie
Clinique La Prairie just launched its CLP Holistic Health supplement line in the U.S., exclusively at Bergdorf Goodman.
Each formula blends the brand’s Holistic Complex—five core compounds including Ashwagandha and Fisetin—with over ten micronutrients and plant extracts like CoQ10 and Spermidine to target cellular longevity, immunity, and rejuvenation.
The goal: bring Swiss longevity science into daily life.
Luxury wellness evolution or just another shelf upgrade?
WHAT ELSE YOU SHOULD KNOW THIS WEEK
Source: Peloton / Twin Health
🤖 Metabolic Move: Peloton teams up with Twin Health to fight metabolic disease using AI digital twins. The system tailors workouts and habits to cut meds and boost lasting health.
💪 Muscle Boost: Targeted EGCG (green tea compound) delivery to muscle cells in old mice cut inflammation and restored strength. The approach avoided liver toxicity seen with regular EGCG.
😴 Cellular Revival: Swiss start-up Vivorum launches Cellular Renewal, a supplement boosting NAD+ (cell energy) and sleep quality. It helps cells repair overnight, linking better rest to slower aging.
🌈 Calm Breakthrough: UCSF scientists found that MM120, a pharmaceutical form of LSD, eased severe anxiety in clinical trials. A single dose cut symptoms by up to six points with only mild side effects.
🥛 Ageless Cells: Maria Branyas Morera, who lived to 117, had cells biologically 23 years younger than her age. Her daily yogurt habit linked to youthful gut bacteria, low inflammation, and strong mitochondrial energy.
WHAT WE’RE BOOKMARKING
📱 Social
Insulin Resistance: The Hidden Cause of Heart Attacks
Most heart attacks don’t happen suddenly; they result from gradual plaque buildup, inflammation, and insulin resistance. Understanding insulin resistance is key to preventing cardiovascular disease and protecting your heart.
— #Heart Surgeon Dr. Philip Ovadia (#@ifixhearts)
11:29 PM • Oct 14, 2025
It's important to remember:
Food first: spinach, pumpkin seeds, cashews, avocado, and dark chocolate.
Lifestyle: reduce stress, limit alcohol and caffeine, support gut health.
Extra support: Magnesium baths (Epsom salt soaks) can calm muscles and the nervous system.
If you
— #Mark Hyman, M.D. (#@drmarkhyman)
10:34 PM • Oct 14, 2025
🎧 Podcasts
That ringing or “clogged” feeling in your ears after a loud concert or other loud exposure is reflective of the first step in hearing loss (… it may take some time to develop). Magnesium supplementation but of course especially ear plugs can both help.
— #Andrew D. Huberman, Ph.D. (#@hubermanlab)
5:46 PM • Oct 14, 2025
📰 Articles
Popeye was on to something!
1-2g of extract (unclear if that needs to come directly from a can or if it goes directly to the biceps...) found to enhance physical performance in 3 different studies.
Exact quote here:
"Spinach extract demonstrated significant improvements in
— #Andy Galpin, PhD (#@DrAndyGalpin)
10:57 AM • Oct 14, 2025
⚙️ Tools to Try
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